Publications

• ­Benzing T, Schumacher B.
  Chronic kidney disease promotes ageing in a multiorgan disease network
  Nat Rev Nephrol. 2023 May 26
  doi: 10.1038/s41581-023-00729-6. Online ahead of print.
   
• Vijg J, Schumacher B, Abakir A, Antonov M, Bradley C, Cagan A, Church G, Gladyshev VN, Gorbunova V, Maslov AY, Reik W, Sharifi S, Suh Y, Walsh K.
  Mitigating age-related somatic mutation burden
  Trends Mol Med. 2023 Apr 28:S1471-4914(23)00072-2
  doi: 10.1016/j.molmed.2023.04.002. Online ahead of print
   
• Bujarrabal A, Sendtner G, Meyer DH, Chatzinikolaou G, Stratigi G, Garinis G, Schumacher B.
  The DREAM complex functions as conserved master regulator of somatic DNA repair capacities.
  Nat Struct Mol Biol. 2023 Mar 23.
  https://doi.org/10.1038/s41594-023-00942-8
   
• Volatier T, Schumacher B, Meshko B, Hadrian K, Cursiefen C, Notara M.
  Short-Term UVB Irradiation Leads to Persistent DNA Damage in Limbal Epithelial Stem Cells, Partially Reversed by DNA Repairing Enzymes.
  Biology (Basel). 2023 Feb 7;12(2):265.
  https://doi.org/10.3390/biology12020265
   
• Clahsen T, Hadrian K, Notara M, Schlereth SL, Howaldt A, Prokosch V, Volatier T, Hos D, Schroedl F, Kaser-Eichberger A, Heindl LM, Steven P, Bosch JJ, Steinkasserer A, Rokohl AC, Liu H, Mestanoglu M, Kashkar H, Schumacher B, Kiefer F, Schulte-Merker S, Matthaei M, Hou Y, Fassbender S, Jantsch J, Zhang W, Enders P, Bachmann B, Bock F, Cursiefen C.
  The novel role of lymphatic vessels in the pathogenesis of ocular diseases.
  Prog Retin Eye Res. 2023 Feb 7:101157.
  https://doi.org/10.1016/j.preteyeres.2022.101157
   
• Selle J, Bohl K, Höpker K, Wilke R, Dinger K, Kasper P, Abend B, Schermer B, Müller R, Kurschat C, Nüsken K, Nüsken E, Meyer D, Savai Pullamsetti S, Schumacher B, Dötsch J, Alejandre Alcazar M,
  Perinatal Obesity Sensitizes for Premature Kidney Aging Signaling
  Int. J. Mol. Sci. 2023, 24(3), 2508;
  https://doi.org/10.3390/ijms24032508
   
• Wang, S., Meyer, D.H. & Schumacher, B.
  Inheritance of paternal DNA damage by histone-mediated repair restriction.
  Nature 613, 365–374 (2023).
  https://doi.org/10.1038/s41586-022-05544-w
   
• Uszkoreit S, Meyer DH, Rechavi O, Schumacher B.
  Sensory neurons safeguard from mutational inheritance by controlling the CEP-1/p53-mediated DNA damage response in primordial germ cells
  bioRxiv 2022.07.19.500657;
  https://doi.org/10.1101/2022.07.19.500657
   
• Kasper P, Selle J, Vohlen C, Wilke R, Kuiper-Makris C, Klymenko O, Bae-Gartz I, Schömig C, Quaas A, Schumacher B, Demir M, Bürger M, Lang S, Martin A, Steffen HM, Goeser T, Dötsch J, Alcazar MAA.
  Perinatal Obesity Induces Hepatic Growth Restriction with Increased DNA Damage Response, Senescence, and Dysregulated Igf-1-Akt-Foxo1 Signaling in Male Offspring of Obese Mice.
  Int J Mol Sci. 2022 May 17;23(10):5609. doi: 10.3390/ijms23105609.
  https://pubmed.ncbi.nlm.nih.gov/35628414/
   
• Vaddavalli PL, Schumacher B.
  The p53 network: cellular and systemic DNA damage responses in cancer and aging.
  Trends Genet. 2022 Jun;38(6):598-612. doi: 10.1016/j.tig.2022.02.010. Epub 2022 Mar 25.
  https://pubmed.ncbi.nlm.nih.gov/35346511/
   
• Volatier T, Schumacher B, Cursiefen C, Notara M.
  UV Protection in the Cornea: Failure and Rescue.
  Biology (Basel). 2022 Feb 10;11(2):278. doi: 10.3390/biology11020278.
  https://pubmed.ncbi.nlm.nih.gov/35205145/
   
• Umansky C, Morellato AE, Rieckher M, Scheidegger MA, Martinefski MR, Fernández GA, Pak O, Kolesnikova K, Reingruber H, Bollini M, Crossan GP, Sommer N, Monge ME, Schumacher B, Pontel LB.
  Endogenous formaldehyde scavenges cellular glutathione resulting in redox disruption and cytotoxicity.
  Nat Commun. 2022 Feb 8;13(1):745. doi: 10.1038/s41467-022-28242-7.
  https://pubmed.ncbi.nlm.nih.gov/35136057/
   
• Soltanmohammadi N, Wang S, Schumacher B.
  Somatic PMK-1/p38 signaling links environmental stress to germ cell apoptosis and heritable euploidy.
  Nat Commun. 2022 Feb 4;13(1):701. doi: 10.1038/s41467-022-28225-8.
  https://www.nature.com/articles/s41467-022-28225-8
   
• Meron E, Thaysen M, Angeli S, Antebi A, Barzilai N, Baur JA, Bekker-Jensen S, Birkisdottir M, Bischof E, Bruening J, Brunet A, Buchwalter A, Cabreiro F, Cai S, Chen BH, Ermolaeva M, Ewald CY, Ferrucci L, Florian MC, Fortney K, Freund A, Georgievskaya A, Gladyshev VN, Glass D, Golato T, Gorbunova V, Hoejimakers J, Houtkooper RH, Jager S, Jaksch F, Janssens G, Jensen MB, Kaeberlein M, Karsenty G, de Keizer P, Kennedy B, Kirkland JL, Kjaer M, Kroemer G, Lee KF, Lemaitre JM, Liaskos D, Longo VD, Lu YX, MacArthur MR, Maier AB, Manakanatas C, Mitchell SJ, Moskalev A, Niedernhofer L, Ozerov I, Partridge L, Passegué E, Petr MA, Peyer J, Radenkovic D, Rando TA, Rattan S, Riedel CG, Rudolph L, Ai R, Serrano M, Schumacher B, Sinclair DA, Smith R, Suh Y, Taub P, Trapp A, Trendelenburg AU, Valenzano DR, Verburgh K, Verdin E, Vijg J, Westendorp RGJ, Zonari A, Bakula D, Zhavoronkov A, Scheibye-Knudsen M.
  Meeting Report: Aging Research and Drug Discovery
  Aging (Albany NY). 2022 Jan 28;14(2):530-543. doi: 10.18632/aging.203859. Epub 2022 Jan 28
  doi.org/10.18632/aging.203859
   
• Rieckher M, Garinis GA, Schumacher B.
  Molecular pagthology of rare progeroid diseases
  Trends Mol Med. 2021 Jul 13;S1471-4914(21)00178-7.
  https://doi.org/10.1016/j.molmed.2021.06.011
   
• Schumacher B, Pothof J, Vijg J, Hoeijmakers JHJ.
  The central role of DNA damage in ageing process.
  Nature. 592, 695-703 (2021). https://doi.org/10.1038/s41586.021.03307-07
   
• Ou HL, Schumacher B.
  Evaluating DNA damage response through immunofluorescence staining of primordial germ cells in Caenorhabditis elegans L1 Larva.
  STAR Protoc. 2021 Apr 5;2(2):100441. eCollection 2021 Jun 18. https://doi.org/10.1016/j.xpro.2021.100441
   
• Schumacher B, Krieg TM.
  The Aging Skin: From Basic Mechanisms to Clinical Applications.
  J Invest Dermatol. 2021 Apr;141(4S):949-950.
  https://doi.org/10.1016/j.jid.2020.12.002.
   
• Meyer DH, Schumacher B.
  BiT age: A transcriptome-based aging clock near the theoretical limit of accurarcy.
  Aging Cell 2021;
  https://doi.org/10.1111/acel.13320
   
• da Silva PFL, Schumacher B.
  Principles of the Molecular and Cellular Mechanisms of Aging.
  J Invest Dermatol. 2021 Jan 28:S0022-202X(20)32362-2.
  https://doi.org/10.1016/j-jid.2020.11.018
   
• Gebel J, Tuppi M, Sänger N, Schumacher B, Dötsch V.
  DNA Dmaged Induced Cell Death in Oocytes
  Molecules. 2020 Dec 3;25(23):E5714.
  https://dio.org/10.3390/molecules25235714
   
• Wang S, Meyer DH, Schumacher B.
  H3K4me2 regulates the recovery of protein biosynthesis and homeostasis following DNA damage.
  Nat Struct Mol Biol 2020 Dec;27(12):1165-1177. https://doi.org/10.1038/s41592-020-00513-1
   
• Lopes AFC, Bozek K, Herholz M, Trifunovic A, Rieckher M#, Schumacher B#.
  A C. elegans model for neurodegeneration in Cockayne syndrome
  Nucleic Acids Research, 2020 Nov 4;48(19):10973-10985, https://doi.org/10.1093/nar/gkaa795
  (#co-corresponding authors)
   
• Meyer DH, Schumacher B.
  A transcriptome based aging clock near the theoretical limit of accuracy.
  BioRxiv 2020; doi: https://doi.org/10.1101/2020.05.29.123430
   
• Umansky C*, Morellato A*, Scheidegger M*, Rieckher M*, Martinefski MR, Fernandez GA, Kolesnikova K, Vesting AJ, Karakasilioti I, Reingruber H, Wei Y, He R, Bollini M, Monge ME, Schumacher B, Pontel LB.
  Endogenous formaldehyde scavenges cellular glutathione resulting in cytotoxic redox disruption
  BioRxiv 2020; dio https://doi.org/10.1101/2020.05.14.090738 (*equal contribution)
   
• Bansal A, Neuhaus R, Izquierdo-Alvarez E, Vorholt D, Feldkötter H, Nolte H, Lohneis P, Büttner R, Krüger M, Pallasch CP, Schumacher B.
  ATM-mediated DNA damage response in macrophages primes phagocytosis and immune checkpoint regulation.
  BioRxiv 2020; doi: https://doi.org/10.1101/2020.03.14.987438
   
• Chatzidoukaki O, Goulielmaki E, Schumacher B, Garinis GA.
  DNA Damage Response and Metabolic Reprogramming in Health and Disease.
  Trends Genet. 2020 Jul 16:S0168-9525(20)30166-9- https://doi.org/10.1016/j.tig.2020.06.018.
   
• da Silva PFL, Schumacher B.
  DNA damage responses in ageing.
  Open Biol. 2019 Nov 29;9(11):190168. doi: 10.1098/rsob.190168. Epub 2019 Nov 20.

• Schumacher B, Vijg J
  Age is in the nucleus
  Nat Metab. 2019. doi: 10.1038/s42255-019-0125-9. Epub 2019 Oct 7

• Rive C, Reina G, Wagle P, Treossi E, Palermo V, Bianco A, Gemma-Delogu L, Rieckher M^#, Schumacher B^#.
  Improved Biocompatibility of Amino-functionalized Graphene Oxide in Caenorhabditis elegans.
  Small 2019, 1902699
  (^#co-corresponding authors)
   
• Bayersdorf R, Schumacher B.
  Recent advances in understanding the mechanisms determining longevity.
  F1000Res. 2019 Aug 9;8. pii: Faculty Rev-1403. doi: 10.12688/f1000research. 19610.1. eCollection 2019.
   
• Ou HL, Kim CS, Uszkoreit S, Wickström SA, Schumacher B.
  Somatic Niche Cells Regulate the CEP-1/p53-Mediated DNA Damage Response in Primordial Germ Cells
  Dev Cell. 2019 Jul 22;50(2):167-183.e8. doi: 10.1016/j.devcel.2019.06.012.
   
• Doll MA, Soltanmohammadi N, Schumacher B.
  ALG-2/AGO-Dependent mir-35 Family Regulates DNA Damage-Induced Apoptosis Through MPK-1/ERK MAPK Signaling Downstreamof the Core Apoptotic Machinery in Caenorhabditis elegans.
  Genetics. 2019 Jul 11. pii: genetics.302458.2019. doi: 10.1534/genetics.119.302458.
   
• Williams AB, Heider F, Messling JE, Riekher M, Bloch W, Schumacher B.
  Restorationof Proteostasis in the Endoplasmic Reticulum Reverses an Inflammation-Like Response to Cytoplasmic DNA in Caenorhabditis elegans.
  Genetics. 2019 Jun 27. pii: genetics.302422.2019. doi: 10.1534/genetics.119302422. [Epub ahead of print]
   
• Jachimowicz RD, Beleggia F, Isensee J, Bhavana VB, Goergens J, Bustos MA, Doll MA, Shenoy A, Checa-Rodriguez C, Wiederstein JL, Baranes-Bachar K, Bartenhagen C, Hertwig F, Teper N, Nishi T, Schmitt A, Distelmaier F, Lüdecke HJ, Albrecht B, Krüger M, Schumacher B, Geiger T, Hoon DSB, Huertas P, Fischer M, Hucho T, Pfeifer M, Ziv Y, Reinhardt HC, Wieczorek D, Shiloh Y.
  UBQLN4 represses homologous recombination and is overexpressed in aggressive tumors.
  Cell, 2019 Jan 24;176, 1-15. doi: 10.1016/j.cell.2018.11.024
   
• Habermehl TL, Parkinson KC, Hubbard GB, Ikeno Y, Engelmeyer JI, Schumacher B, Mason JB.
  Extension of longevity and reduction of inflammation is ovarian-dependent, but germ cell-independent in post-reproductive female mice.
  Geroscience. 2018 Dec 13. doi: 10.1007/s11357-018-0049-4. [Epub ahead of print]
   
• Torgovnick A, Schiavi A, Shaik A, Kassahun H, Maglioni S, Rea SL, Johnson TE, Reinhardt HC, Honnen S, Schumacher B, Nilsen H, Ventura N.
  Mitochondrial stress prevents C. elegans germline apoptosis via BRCA1/BARD1 tumor suppressor genes independently from its pro-longevity effect.
  EMBO Rep. 2018, e45856. doi: 10.15252/embr.201845856. Epub 2018 Oct 26.
   
• Torgovnick A^#, Heger JM, Liaki V, Isensee J, Schmitt A, Knittel G, Riabinska A, Beleggia F, Laurien L, Leeser U, Jüngst C, Siedek F, Vogel W, Klümper N,
  Nolte H, Wittersheim M, Tharun L, Castiglione R, Krüger M, Schauss A,
  Perner S, Pasparakis M, Büttner R, Persigehl T, Hucho T, Herter-Sprie GS, Schumacher B^#, Reinhardt HC^#.
  The Cdkn1a^SUPER mouse as a novel tool to study p53-mediated tumor suppression.
  Cell Rep. 2018 Oct 23;25(4), 1027-1039. doi: 10.1016/j.celrep.2018.09.079
  (^#co-corresponding authors)
   
• Rieckher M, Markaki M, Princz A, Schumacher B, Tavernarakis N.
  Maintenance of Proteostasis by P Body-Mediated Regulation of eIF4E Availability during Aging in Caenorhabditis elegans.
  Cell Rep. 2018 Oct 2;25(1):199-211.e6. doi: 10.1016/j.celrep.2018.09.009.
• Notara M, Behboudifard S, Kluth MA, Maßlo C, Ganss, Frank MH, Schumacher B, Cursiefen C. UV light-blocking contact lenses protect against short-term UVB-induced limbal stem cell niche damage and inflammation.
  Sci Rep. 2018 Aug 22,8(1):12564. doi:10.1038/s41598-018-30021-8.
   
• Williams AB, Schumacher B.
  Nematoda: The Caenorhabditis elegans Model for Innate Immunity Interactions Between Worms and Pathogens, and Their Responses to Immunogenic Damage
  Advances in Comparative Immunology, 2018
   
• Bianco J, Schumacher B.
  MPK-1/ERK pathway regulates DNA damage response during development through DAF-16/FOXO
  Nucleic Acids Res. 2018. doi:10.1093/nar/gky404
• Lohmann G, Schumacher B, Herling M
  Nucleotide excision repair as a targetable vulnerability in leukemia
  Oncotarget. 2017 Dec 6;8(70):114420-114421. doi: 10.18632/oncotarget.22998. eCollection 2017 Dec 29.
   
• Rieckher M, Psycharakis S, Ancora D, Liapis E, Zacharopoulos A, Ripoll J, Tavernarakis N, Zacharakis G
  Demonstrating improved multiple transport-mean-free-path imaging capabilities of light sheet microscopy in the quantification of fluorescence dynamics
  Biotechnol J. 2017 Nov 23. doi: 10.1002/biot.201700419. [Epub ahead of print]
   
• Ou HL, Schumacher B
  DNA damage responses and p53 in the aging process
  Blood 2017 :blood-2017-07-746396; doi: 10.1182/blood-2017-07-746396
   
• Edifizi D, Schumacher B
  Omics Approaches for Identifyiung Physiological Adaptations to Genome Instability in Aging
  Int. J. Mol. Sci. 2017, 18(11), 2329; doi: 10.3390/ijms18112329
   
• Edifizi D, Nolte H, Babu V, Castells-Roca L, Mueller MM, Brodesser S, Krüger N, Schumacher B
  Multilayered reprogramming in response to persistent DNA damage in C. elegans
  Cell Reports. 2017 Aug 29;20(9):2026-2043
   
• Wilson DM 3rd*, Rieckher M*, Williams AB, Schumacher B.
  Systematic analysis of DNA crosslink repair pathways during development in aging in C. elegans
  Nucleic Acids Res. 2017. doi:10.1093/nar/gkx660 (*equal contribution)
   
• Rieckher M, Bujarrabal A, Doll MA, Soltanmohammadi N, Schumacher B.
  A simple answer to complex questions: C. elegans as an experimental model for examining the DNA damageresponse and disease genes.
  J Cell Physiol. 2017 May 2. doi: 10.1002/jcp.25979. [Epub ahead of print]
   
• Garinis GA, Schwer B, Schumacher B.
  Editorial: DNA damage & immunity.
  Mech Ageing Dev. 2017 Apr 23. pii: S0047-6374(17)30097-0. doi: 10.1016/j.mad.2017.04.006. [Epub ahead of print]
   
• Bujarrabal A, Schumacher B.
  Tracking senescent cells: A new biomarker assay opens new avenues in senescence research.
  Mech Ageing Dev. 2017 Feb 1. pii: S0047-6374(16)30293-7. doi: 10.1016/j.mad.2017.01.009. [Epub ahead of print]
   
• Williams AB, Schumacher B.
  DNA damage responses and stress resistance: Concepts from bacterial SOS to metazoan immunity.
  Mech Ageing Dev. 2016 Sep 26. pii: S0047-6374(16)30174-9. doi: 10.1016/j.mad.2016.09.007. [Epub ahead of print]

• Bujarrabal A, Schumacher B.
  Hormesis running hot and cold.
  Cell Cycle. 2016 Sep 29:0. [Epub ahead of print] 
   
• Ackermann L, Schell M, Pokrzywa W, Kevei E, Gartner B, Schumacher B#, Hoppe T#.
  E4 ligase-specific ubiquitination hubs coordinate DNA double-strand-break repair and apoptosis.
  Nat Struct Mol Biol. 2016 Sep 26. doi: 10.1038/nsmb.3296. [Epub ahead of print] (#co-corresponding authors)
   
• Lohmann G, Vasyutina E, Bloehdorn J, Reinart N, Schneider JI, Babu V, Knittel G, Crispatzu G, Mayer P, Prinz C, Biersack B, Efremov DG, Chessa L, Herling CD, Stilgenbauer S, Hallek M, Schobert R, Reinhardt HC, Schumacher B, Herling M.
  Targeting transcription-coupled nucleotide excision repair overcomes resistance in chronic lymphocytic leukemia.
  Leukemia. 2017 May;31(5):1177-1186. doi: 10.1038/leu.2016.294. Epub 2016 Oct 24.
   
• Fernández-Majada V, Welz PS, Ermolaeva MA, Schell M, Adam A, Dietlein F, Komander D, Büttner R, Thomas RK, Schumacher B, Pasparakis M.
  The tumour suppressor CYLD regulates the p53 DNA damage response.
  Nat Commun. 2016 Aug 26;7:12508. doi: 10.1038/ncomms12508.
   
• Jokic M, Vlasic I, Rinneburger M, Klumper N, Spiro J, Vogel W, Offermann A, Kuempers C, Fritz C, Schmitt A, Riabinska A, Wittersheim M, Michels S, Ozretic L, Florin A, Welcker D, Akyuz MD, Nowak M, Erkel M, Wolf J, Buttner R, Schumacher B, Thomale J, Persigehl T, Maintz D, Perner S, Reinhardt HC
  Ercc1 Deficiency Promotes Tumorigenesis and Increases Cisplatin Sensitivity in a TP53 Context-specific Manner
  Mol Cancer Res. 2016 Aug 11. pii: molcanres.0094.2016. [Epub ahead of print]
   
• Nakad R, Schumacher B
  DNA Damage Response and Immune Defence: Links and Mechanisms
  Front. Genet. 09 Aug 2016. doi: 10.3389/fgene.2016.00147
   
• Willams AB, Schumacher B
  p53 in the DNA-Damage-Repair Process.
  Cold Spring Harb Perspect Med. 2016 Apr 5. pii: a026070. doi: 10.1101/cshperspect.a026070. [Epub ahead of print]
   
• Barzilai A, Schumacher B, Shiloh, Y
  Genome Instability: Linking Aging and Brain Degeneration.
  Mech Ageing Dev. 2016 Mar 31. pii: S0047-6374(16)30039-2. doi: 10.1016/j.mad.2016.03.011. [Epub ahead of print]
   
• Babu V, Schumacher B
  A C. elegans homolog for the UV-hypersensitivity syndrome disease gene UVSSA.
  DNA Repair (Amst). 2016 Mar 25;41:8-15. doi: 10.1016/j.dnarep.2016.03.008. [Epub ahead of print]
   
• Braun F, Rinschen MM, Bartels V, Frommolt P, Habermann B, Hoeijmakers JH, Schumacher B, Dollé ME, Müller RU, Benzing T, Schermer B, Kurschat CE.
  Altered lipid metabolism in the aging kidney identified by three layered omic analysis.
  Aging (Albany NY). 2016 Feb 16.
   
• Ribezzo F, Shiloh Y, Schumacher B.
  Systemic DNA damage responses in aging and diseases.
  Semin Cancer Biol. 2016 Jan 7. pii: S1044-579X(15)30005-5. doi: 10.1016/j.semcancer.2015.12.005

   

• Nkuipou-Kenfack E, Bhat A, Klein J, Jankowski V, Mullen W, Vlahou A, Dakna M, Koeck T1 Schanstra JP, Zürbig P, Rudolph KL, Schumacher B, Pich A, Mischak H.
  Identification of ageing-associated naturally occurring peptides in human urine.
  Oncotarget 29 Sep 2015; doi: 10.18632/oncotarget.5896
• Björn Schumacher
  Das Geheimnis des menschlichen Alterns
  Die überraschenden Erkenntnisse der noch jungen Alternsforschung
  ISBN: 978-3-89667-524-8 

• Edifizi D, Schumacher B
  Genome Instability in Development and Aging: Insights from Nucleotide Excision Repair in Humans, Mice, and Worms
  Biomolecules 2015, 5, 1855-1869; doi:10.3390/biom5031855

• Torgovnick A, Schumacher B.
  DNA repair mechanisms in cancer development and therapy.
  Front Genet. 2015 Apr 23;6:157. doi: 10.3389/fgene.2015.00157. eCollection 2015.

   

• Frommolt P, Schumacher B.
  Wormpath: searching for molecular interaction networks in Caenorhabditis elegans.
  Source Code Biol Med. 2015 Apr 2;10:5. doi: 10.1186/s13029-015-0034-6. eCollection 2015.

   

• Castells-Roca L, Mueller M, Schumacher B.
  Longevity through DNA damage tolerance.
  Cell Cycle. 2015;14(4):467-8. doi: 10.1080/15384101.2015.1006543.

   

• Ermolaeva MA, Dakhovnik A, Schumacher B.
  Quality control mechanisms in cellular and systemic DNA damage responses.
  Ageing Res Rev. 2015 Jan 2. pii: S1568-1637(14)00144-5. doi: 10.1016/j.arr.2014.12.009. [Epub ahead of print]

   

• Williams AB.
  Spontaneous mutation rates come into focus in Escherichia coli.
  DNA Repair (Amst). 2014 Dec;24C:73-79. doi: 10.1016/j.dnarep.2014.09.009. Epub 2014 Oct 11.

   

• Babu V, Hofmann K, Schumacher B.
  A C. elegans homolog of the Cockayne syndrome complementation group A gene
  DNA Repair (Amst). 2014 Dec;24:57-62. doi: 10.1016/j.dnarep.2014.09.011. Epub 2014 Nov 8.

   

• Mueller MM*, Castells-Roca L*, Babu V, Ermolaeva MA, Müller RU, Frommolt P, Williams AB, Greiss S, Schneider JI, Benzing T, Schermer B, Schumacher B.
  DAF-16/FOXO and EGL-27/GATA promote developmental growth in response to persistent somatic DNA damage.
  Nat Cell Biol. 2014 Nov 24. doi: 10.1038/ncb3071. (*equal contribution)

   

• Nkuipou-Kenfack E, Koeck T, Mischak H, Pich A, Schanstra JP, Zürbig P, Schumacher B.
  Proteome analysis in the assessment of ageing.
  Ageing Res Rev. 2014 Sep 22. pii: S1568-1637(14)00105-6. doi:10.1016/j.arr.2014.09.002. 

   

• Ermolaeva MA, Schumacher B.
  Insights from the worm: The C. elegans model for innate immunity. Semin Immunol (2014)

   

• Behrens A, van Deursen JM, Rudolph KL, Schumacher B.
  Impact of genomic damage and ageing on stem cell function.
  Nat Cell Biol. 2014 Feb 28;16(3):201-7. doi: 10.1038/ncb2928.

   

• Ermolaeva MA, Schumacher B.
  Systemic DNA damage responses: organismal adaptations to genome instability.
  Trends Genet. 2014 Mar;30(3):95-102. doi: 10.1016/j.tig.2013.12.001. Epub 2014 Jan 15.

   

• Wolters S, Ermolaeva MA, Bickel JS, Fingerhut JM, Khanikar J, Chan RC, Schumacher B.
  Loss of Caenorhabditis elegans BRCA1 Promotes Genome Stability During Replication in smc-5 Mutants.
  Genetics. 2014 Apr;196(4):985-99. doi: 10.1534/genetics.113.158295. Epub 2014 Jan 14.

   

• Ermolaeva M, Schumacher B.
  The innate immune system as mediator of systemic DNA damage responses.
  Communicative & Integrative Biology 2013; 6:e26926; doi:10.4161/cib.26926

   

• Ermolaeva MA, Segref A, Dakhovnik A, Ou HL, Schneider JI, Utermöhlen O, Hoppe T, Schumacher B.
  DNA damage in germ cells induces an innate immune response that triggers systemic stress resistance.
  Nature. 2013 Sep 19;501(7467):416-20. doi: 10.1038/nature12452.

   

• Schermer B, Bartels V, Frommolt P, Habermann B, Braun F, Schultze JL, Roodbergen M, Hoeijmakers JH, Schumacher B, Nürnberg P, Dollé ME, Benzing T, Müller RU, Kurschat CE.
  Transcriptional profiling reveals progeroid Ercc1-/Δ mice as a model system for glomerular ageing.
  BMC Genomics. 2013 Aug 16;14:559. doi: 10.1186/1471-2164-14-559.

   

• Wolters S, Schumacher B
  Genome maintenance and transcription integrity in aging and disease.
  Front Genet. 2013;4:19. doi: 10.3389/fgene.2013.00019. Epub 2013 Feb 25

   

• Schumacher B
  DNA-Reparatur und Alterung
  Medgen. 2012; 24: 289-296

   

• Höpker K, Hagmann H, Khurshid S, Chen S, Hasskamp P, Seeger-Nukpezah T, Schilberg K, Heukamp L, Lamkemeyer T, Sos ML, Thomas RK, Lowery D, Roels F, Fischer M, Liebau MC, Resch U, Kisner T, Röther F, Bartram MP, Ulrich Müller R, Fabretti F, Kurschat P, Schumacher B, Gaestel M, Medema RH, Yaffe MB, Schermer B, Christian Reinhardt H, Benzing T
  AATF/Che-1 acts as a phosphorylation-dependent molecular modulator to repress p53-driven apoptosis.
  EMBO J. 2012 Aug 21.

   

• Reinhardt HC, Schumacher B
  The p53 network: Cellular and systemic DNA damage responses in aging and cancer.
  Trends Genet. 2012 Mar;28(3):128-36.

   

• Schwer B, Schumacher B, Lombard DB, Xiao C, Kurtev MV, Gao J, Schneider JI, Chai H, Bronson RT, Tsai LH, Deng CX, Alt FW.
  Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity.
  Proc Natl Acad Sci U S A. 2010 Nov 22.

   

• Motameny S, Wolters S, Nürnberg P, Schumacher B.
  Next Generation Sequencing of miRNAs Strategies, Resources and Methods.
  Genes. 2010; 1(1):70-84.

   

• Lans H, Marteijn JA, Schumacher B, Hoeijmakers JH, Jansen G, Vermeulen W.
  Involvement of global genome repair, transcription coupled repair, and chromatin remodeling in UV DNA damage response changes during development.
  PLoS Genet. 2010 May 6;6:e1000941.

   

• Schumacher B
  Transcription-blocking DNA damage in aging: a mechanism for hormesis.
  Bioessays. 2009 Dec;31(12):1347-56.

   

• Garinis GA, Schumacher B
  Transcription-blocking DNA damage in aging and longevity.
  Cell Cycle. 2009 Jul 20;8(14).

   

• Garinis GA, Uittenboogaard LM, Stachelscheid H, Fousteri M, van Ijcken W, Breit TM, van Steeg H, Mullenders LHF, van der Horst GTJ, Brüning JC, Niessen CM, Hoeijmakers JHJ and Schumacher B
  Persistent transcription-blocking DNA lesions trigger somatic growth attenuation associated with longevity.
  Nature Cell Biol. 2009 May;11(5):604-15.

   

• Schumacher B, Hoeijmakers JH, Garinis GA
  Sealing the gap between nuclear DNA damage and longevity.
  Cell Endocrinol. 2009 Feb 5;299(1):112-7. Epub 2008 Nov 5.

   

• Schumacher B, van der Pluijm I, Moorhouse MJ, Rasile Robinson A, Suh Y, Breit TM, van Steeg H, Niedernhofer LJ, van Ijcken W, Bartke A, Spindler SR, Hoeijmakers JHJ, van der Horst GTJ and Garinis GA
  Delayed and accelerated aging share common longevity assurance mechanisms.
  PLoS Genet. 2008 Aug 15;4(8):e1000161.

   

• Greiss S#, Schumacher B#, Grandien K, Rothblatt J and Gartner A
  Transcriptional profiling in C. elegans cep-1/p53 dependent apoptosis as a primordial function of p53 like genes.
  BMC Genomics. 2008 Jul 15;9(1):334.

   

• Schumacher B, Garinis G, Hoeijmakers J
  Age to survive: DNA damage and aging.
  Trends Genet. 2008 Feb;24(2):77-85.

   

• Garinis G, Patil C, Schumacher B
  "The molecular basis of aging": the Boehringer Ingelheim Fonds 95th International Titisee Conference.
  Mech Ageing Dev. 2007 Jul-Aug;128(7-8):469-75.

   

• Schumacher B & Gartner A
  Translational regulation of p53 as a potential tumor therapy target.
  Future Oncology, 2006;2(1):145-153.

   

• Schumacher B, Hanazawa M, Lee M, Nayak S, Volkmann K, Hofmann R, Hengartner M, Schedl T, Gartner A
  Translational Repression of C. elegans p53 by GLD-1 regulates DNA damage induced apoptosis
  Cell, 11 February 2005; 120: 357-368.

   

• Schumacher B, Schertel C, Wittenburg N, Tuck S, Mitani S, Gartner A, Conradt B, Shaham S
  C. elegans ced-13 can promote apoptosis and is induced in response to DNA damage.
  Cell Death Differ. 2005 Feb;12(2):153-61.

   

• Schumacher B, Alpi A, Gartner A
  Cell cycle: check for asynchrony.
  Curr Biol. 2003 Jul 15;13(14):R560-2.

   

• Gartner A, Alpi A, Schumacher B
  Promgrammed cell death in C. elegans.
  Genetics of Apoptosis, Grimm S (ed.), BIOS Scientific Publishers Limited, 2003, 155-175

   

• Schumacher B, Hofmann K, Boulton S, Gartner A
  The C. elegans homolog of the p53 tumor suppressor is required for DNA damage-induced apoptosis.
  Curr Biol. 2001 Oct 30;11(21):1722-7.

   

Last Update: October 10 2019 16:00.