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Björn Schumacher

Das Geheimnis des menschlichen Alterns

Die überraschenden Erkenntnisse der noch jungen Alternsforschung

DNA Damage and Ageing

We are investigating the molecular mechanism of aging. Ageing is strongly correlated with a host of human pathologies, most prominently cancer and neurodegenerative diseases such as Alzheimer's and Parkinson's, as well as general functional decline. It is, therefore, of outstanding interest to further our understanding of the mechanisms underlying human ageing. DNA damage has been shown to play a central role both in cancer and, more recently, in premature ageing. The causal role of DNA damage in cancer and aging is particularly apparent in human patients that have inborn deficiencies in nucleotide excision repair (NER). There are two distinct branches of initial damage recognition; global genome (GG) NER scans the entire genome for helix-distorting DNA lesions, whereas transcription-coupled repair (TCR) detects lesions in actively transcribed genes. Strikingly, GG-NER defects leads to skin cancer prone Xeroderma pigmentosum (XP) whereas defective TCR gives rise to premature ageing (progeroid) syndromes Cockayne syndrome (CS) and trichothiodystrophy (TTD). To unravel the molecular mechanism through which DNA damage contributes to ageing we are using the genetic model organism Caenorhabditis elegans as well as mammalian disease models. 

Excision repair in cancer and aging. UV lesions and helix-distorting chemical adducts are recognized and repaired by a multi-protein nucleotide excision repair (NER) complex comprising two pathways: global genome (GG) NER and transcription-coupled excision repair (TCR). Patients who have a defective GG-NER pathway are highly susceptible to skin cancer, whereas defects in TCR lead to progeroid syndromes. Reproduced from Schumacher, Bioessays 2009
Excision repair in cancer and aging. UV lesions and helix-distorting chemical adducts are recognized and repaired by a multi-protein nucleotide excision repair (NER) complex comprising two pathways: global genome (GG) NER and transcription-coupled excision repair (TCR). Patients who have a defective GG-NER pathway are highly susceptible to skin cancer, whereas defects in TCR lead to progeroid syndromes. Reproduced from Schumacher, Bioessays 2009

Lab-News

Björn Schumacher on TV at BR-Alpha

Björn Schumacher was on TV at the German channel BR-Alpha

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„Im Gespräch“ radio interview with Björn Schumacher

Björn Schumacher was interviewed by "Deutschlandradio Kultur" regarding Ageing research and it's progress in the past years.

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The Programme Flyer for the 3rd Annual Meeting of CodeAge/aDDress and MAriAGE is now online

The official flyer can now be downloaded from our website. Please use <link...

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Björn Schumacher featured on Cologne Newspaper "Express"

Prof. Björn Schumacher was featured on the local newspaper "Express" in an article about his book "Das Geheimnis des menschlichen Alterns" (The secret...

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Workshop on "Genetic Model Organisms in Ageing Research"

This Workshop will take place on 21 September, 2015 in Cologne, Germany.

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Arturo Bujarrabal awarded with scholarship

We congratulate Arturo Bujarrabal for being awarded with the scholarship of the DAAD and the Fundación "la Caixa" for Doctoral Candidates

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Björn Schumacher publishes "The secret of human ageing"

Björn Schumacher publishes "The secret of human ageing". Download the Podcast here.

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