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Björn Schumacher

Das Geheimnis des menschlichen Alterns

Die überraschenden Erkenntnisse der noch jungen Alternsforschung

Björn Schumacher

The Mystery of Human Aging

Surprising Insights from a Science That's Still Young

ISBN: 978-1-62894-282-8

DNA Damage and Ageing

The Institute for Genome Stability in Ageing and Disease (IGSAD) is devoted to investigating the molecular mechanism of ageing. Ageing is strongly correlated with a host of human pathologies, most prominently cancer and neurodegenerative diseases such as Alzheimer's and Parkinson's, as well as general functional decline. It is, therefore, of outstanding interest to further our understanding of the mechanisms underlying human ageing.

DNA damage has been shown to play a central role both in cancer and, more recently, in premature ageing. The causal role of DNA damage in cancer and aging is particularly apparent in human patients that have inborn deficiencies in nucleotide excision repair (NER). There are two distinct branches of initial damage recognition; global genome (GG)-NER scans the entire genome for helix-distorting DNA lesions, whereas transcription-coupled NER (TC-NER) detects lesions in actively transcribed genes. Strikingly, GG-NER defects lead to skin cancer prone Xeroderma pigmentosum (XP) whereas defective TC-NER gives rise to premature ageing (progeroid) syndromes Cockayne syndrome (CS) and trichothiodystrophy (TTD).

To unravel the molecular mechanism through which DNA damage contributes to ageing we are using the genetic model organism Caenorhabditis elegans as well as mammalian disease models. 

Excision repair in cancer and aging. UV lesions and helix-distorting chemical adducts are recognized and repaired by a multi-protein nucleotide excision repair (NER) complex comprising two pathways: global genome (GG) NER and transcription-coupled excision repair (TCR). Patients who have a defective GG-NER pathway are highly susceptible to skin cancer, whereas defects in TCR lead to progeroid syndromes. Reproduced from Schumacher, Bioessays 2009
Excision repair in cancer and aging. UV lesions and helix-distorting chemical adducts are recognized and repaired by a multi-protein nucleotide excision repair (NER) complex comprising two pathways: global genome (GG) NER and transcription-coupled excision repair (TCR). Patients who have a defective GG-NER pathway are highly susceptible to skin cancer, whereas defects in TCR lead to progeroid syndromes. Reproduced from Schumacher, Bioessays 2009

Lab-News

Nihan Erden awarded with the DAAD Fellowhip

Congratulations to Nihan Erden who received the DAAD PhD Fellowship. Nihan joins us from the Koç University School of Medicine in Istanbul.


Shoma Ishikawa awarded with the Humboldt Research Fellowship

Congratulations to Shoma Ishikawa who has been awarded the prestigious Humboldt Fellowship of the Alexander von Humboldt Foundation. Shoma joins our...


Thomas Krieg and Björn Schumacher edit a special issue of the Journal of Investigative Dermatology on Aging and the Skin.


David Mayer and Björn Schumacher developed BiT Age, a highly precise ‘clock’ for measuring biological age


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Prof. Dr. Björn Schumacher receives the Eva Luise Köhler Research Award for Rare Diseases on 26 Februar 2019

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Björn Schumacher publishes "The Mystery of Human Aging"

Björn Schumacher publishes "The Mystery of Human Aging"

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